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Major Depression
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Definition: Major depressive disorder consists of one or more major depressive episodes each of which lasts at least 2 weeks. The most prominent symptoms of major depressive disorder are depressed mood and loss of interest or pleasure. Patients also tend to have other symptoms, but these vary from person-to-person.  Insomnia and weight loss often accompany major depression, but depressed patients may also gain weight and sleep excessively. 

Major depression encompasses disorders that were once conceptualized separately.  A form sometimes called melancholia, is most common among older adults people, as are depressions characterized by psychotic features such as delusions and hallucinations. Anxiety symptoms such as panic attacks, phobias, and obsessions also often found mixed with depressive symptoms, making diagnosis an inexact art at times.  Untreated major depressive episodes often last about 9 months. Approximately 85% of persons with major depression will get better within 2 years of the first episode, but at least 50 percent of depressions will recur, and after three or more episodes the odds of recurrence within 3 years increases to around 75% if the patient has not had preventive treatment.   The risk of suicide makes it important to treat major depression.

Also Known As: Major Affective Disorder, Involutional Melancholia (melancholia in older persons), psychotic depression (when psychotic symptoms are included)

Common Misspellings: melencholia, melancolia, depresion, depresson

Related Resources:

Depression Resources
Lots of resources about Major Depression and other forms of depression

Antidepressant Medications
One of the effective ways to treat Major Depression

Exercise more effective than Zoloft
for treating depression and preventing its return.

Treat Your Depression over the Phone
Does it really work?  It seems to help mild-to-moderate depression.

What if It's Not Depression?
Chronic fatigue, thyroid problems & autoimmune disorders can mimic depression.

Elsewhere on the Web:

Depression Resources at MEDLINEPlus
Resources chosen by NIH for their content.

About's Depression Site
A site with even more information on Depression

Wing of Madness - A Depression Guide
A site which emphasizes the biological basis for depression, but acknowledges the role of psychotherapy as well.


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