FDA issues an advisory on the Use of Triptans and Antidepressants
The U.S.Food and Drug Administration has issued a public health advisory about potential risks of taking certain migraine medications - triptans - together with certain antidepressants. The advisory states, "A life-threatening condition called serotonin syndrome may occur when triptans are used together with a SSRI or a SNRI."
Serotonin syndrome occurs when the body has too much of serotonin, a chemical found in the nervous system. Serotonin syndrome may be more likely to occur when starting or increasing the dose of a triptan, SSRI or SNRI. Symptoms of serotonin syndrome may include:
- restlessness
- hallucinations
- loss of coordination
- fast heart beat
- rapid changes in blood pressure
- increased body temperature
- overactive reflexes
- nausea
- vomiting
- diarrhea
Read more about this advisory from Teri Robert - the About Guide to Migraines

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